Saffron Extract (affron® / Satiereal®)

Sleep & mood

Function & benefits

An extract rich in crocin and safranal; a meta-analysis of randomised trials suggests it supports a positive mood in adults with mild to moderate low mood, and a clinical trial suggests it reduced snacking and increased fullness.

Dosage & how to use

Recommended dose	28–30 mg of standardised extract daily
Best time to take	In the morning with breakfast or at lunch
Frequency	Once daily (or split into two doses)

Best forms to choose

Standardised saffron extract (such as affron® or Satiereal®) in capsules.

Important warnings

Do not exceed the dose: very large amounts of saffron (several grams) are toxic

Not for use in supplement doses during pregnancy, as it may trigger uterine contractions; avoid during breastfeeding

Avoid it if you have bipolar disorder

Drug interactions

Important warning: do not combine it with antidepressants (SSRIs, SNRIs) unless under medical supervision; it may strengthen blood pressure drugs and blood thinners.

View in the supplements guide

Related supplements

Scientific references

Tóth B et al. Planta Med 2019 (meta-analysis) — PMID: 30036891
Gout B et al. Nutr Res 2010 — PMID: 20579522

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.