5-HTP (5-Hydroxytryptophan)

Sleep & mood

Function & benefits

A natural intermediate compound from the seeds of the Griffonia plant that is converted directly in the brain into the neurotransmitter serotonin, supporting a stable mood and a regular sleep cycle.

Dosage & how to use

Recommended dose	50–100 mg (start with 50 mg)
Best time to take	30 minutes before bed with a light snack
Frequency	Once daily

Important warnings

May cause nausea or mild digestive discomfort

Not for pregnant or breastfeeding women or people taking Parkinson’s medication (carbidopa)

Drug interactions

Critical clinical warning: never take it together with antidepressants (SSRIs, SNRIs, MAOIs) or St John’s wort, to avoid serotonin syndrome, which can be life-threatening.

Scientific references

Schruers K et al. Psychiatry Res 2002 — PMID: 12559480
NIH National Library of Medicine (StatPearls): Serotonin Syndrome

View in the supplements guide

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📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.