Papain (Papaya Enzyme)

Digestive enzymes

Function & benefits

A protein-digesting enzyme taken from the sap of unripe papaya fruit; it helps break down the proteins in meat and legumes, and a clinical study of a papaya preparation suggests it eases indigestion, bloating and constipation.

Dosage & how to use

Recommended dose	100–300 mg with a meal
Best time to take	With the first bite of a protein-rich main meal
Frequency	With main meals

Best forms to choose

Pure papain powder standardised in USP units, or chewable papaya tablets.

Important warnings

Avoid it if you are allergic to papaya, latex, kiwi or figs

Not for use in supplement doses during pregnancy

Avoid it with an active ulcer

Drug interactions

It may strengthen warfarin and raise the INR; monitor your values when combining them.

View in the supplements guide

Related supplements

Scientific references

Muss C et al. Neuro Endocrinol Lett 2013 — PMID: 23524622

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.