Bromelain (Pineapple Enzyme)

Digestive enzymes

Function & benefits

A mix of protein-digesting enzymes taken from pineapple stems; with food it helps digest protein, and between meals it is used to support joint comfort and ease swelling, and a clinical study suggests it eases mild knee discomfort and improves well-being in healthy adults.

Dosage & how to use

Recommended dose	500 mg daily
Best time to take	For digestion: with a protein-rich meal. For joint comfort: between meals on an empty stomach
Frequency	1–2 times daily

Best forms to choose

Bromelain standardised for enzyme activity (at least 2400 GDU/g), in capsules or tablets.

Important warnings

Avoid it if you are allergic to pineapple, latex, papain or grass pollen

Stop two weeks before surgery, and avoid it with an active ulcer

Avoid during pregnancy and breastfeeding

Drug interactions

It increases the absorption of some antibiotics (amoxicillin, tetracycline) and may strengthen blood thinners and antiplatelet drugs.

View in the supplements guide

Related supplements

Scientific references

Walker AF et al. Phytomedicine 2002 — PMID: 12587686
Pavan R et al. Biotechnol Res Int 2012 (review) — PMID: 23304525

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.