Vitamin K2 (Menaquinone-7 / MK-7)

Bones & blood vessels

Function & benefits

Vitamin K contributes to normal blood clotting and the maintenance of normal bones (EFSA-authorised claims); it activates osteocalcin, which binds calcium in bone, and matrix GLA protein, which limits calcium deposits in artery walls.

Dosage & how to use

Recommended dose	90–180 µg daily
Best time to take	With a meal that contains fat, preferably with vitamin D3
Frequency	Once daily

Best forms to choose

Natural menaquinone-7 (MK-7) from natto or fermentation (such as MenaQ7®), with a blood half-life of up to 72 hours compared with a few hours for MK-4.

Important warnings

Strictly not for people taking vitamin K antagonists (warfarin, acenocoumarol)

It does not interfere with newer anticoagulants (such as apixaban and rivaroxaban), but always tell your doctor

Drug interactions

Anticoagulant warning: it weakens vitamin K antagonists (warfarin, acenocoumarol) and raises the risk of clots; do not combine them.

View in the supplements guide

Related supplements

Scientific references

EFSA Journal 2009;7(10):1228 (vitamin K and maintenance of bone)
Knapen MH et al. Osteoporos Int 2013 — PMID: 23525894

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.