Citicoline (CDP-Choline)
Focus & memoryFunction & benefits
A compound that splits after absorption into choline (for making acetylcholine) and cytidine (which becomes uridine in the brain to build the phospholipids of nerve cell membranes), supporting focus and efficient information processing.
Dosage & how to use
| Recommended dose | 250–500 mg daily (EU authorised maximum for supplements 500 mg) |
| Best time to take | In the morning with breakfast or lunch |
| Frequency | 1–2 times daily |
Best forms to choose
Pure fermented citicoline (such as Cognizin®), authorised as a novel food in the EU.
Important warnings
Stick to the EU authorised limit of 500 mg a day
Rarely causes a passing headache or mild insomnia if taken late
Not intended for children, pregnant or breastfeeding women
Drug interactions
It may strengthen levodopa in Parkinson's disease, which may require a dose adjustment under medical supervision.
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Scientific references
- Nakazaki E et al. J Nutr 2021 — PMID: 33978188
Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)
⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.