Alpha-GPC (L-Alpha Glycerylphosphorylcholine)
Focus & memoryFunction & benefits
A choline carrier that crosses the blood-brain barrier more efficiently than ordinary choline forms; it raises acetylcholine, the main neurotransmitter for learning, memory and reaction speed, and supports muscle motor-unit activation during exercise.
Dosage & how to use
| Recommended dose | 300–600 mg daily |
| Best time to take | In the morning or 45 minutes before mental or physical effort, with a light source of fat |
| Frequency | 1–2 times daily |
Best forms to choose
Standardized capsules of 50% or 99% purity; keep the container closed, as the substance absorbs moisture strongly and clumps quickly.
Important warnings
High doses may cause a mild headache or, rarely, heartburn
Observational studies suggest chronic high-dose use may raise blood TMAO; best used in cycles or when needed
Drug interactions
It may counteract anticholinergic drugs and may add to the effect of Alzheimer's medication (cholinesterase inhibitors).
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Scientific references
- Bellar D et al. J Int Soc Sports Nutr 2015 — PMID: 26582972
- NIH Office of Dietary Supplements (ODS): Choline Fact Sheet
Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)
⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.