Phosphatidylserine (PS)
Focus & memoryFunction & benefits
A natural phospholipid that is a key building block of nerve cell membranes; it helps support nerve signalling and neurotransmitter release, and studies suggest it limits sharp rises in the stress hormone cortisol during physical and mental strain.
Dosage & how to use
| Recommended dose | 300–400 mg daily |
| Best time to take | Split with meals, or in the evening to support relaxation |
| Frequency | Once daily or in split doses |
Best forms to choose
Phosphatidylserine derived from sunflower or soy lecithin, rather than the older bovine sources.
Important warnings
A very safe supplement for long-term use
High doses taken late may cause mild drowsiness or disturbed sleep
Avoid soy-derived products if you have a soy allergy
Drug interactions
It may interact with anticholinergic drugs and Alzheimer's medication (cholinesterase inhibitors). It may slightly thin the blood, so take care with anticoagulants.
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Scientific references
- Kato-Kataoka A et al. J Clin Biochem Nutr 2010 — PMID: 21103034
- US FDA: Qualified health claim for phosphatidylserine and cognitive function (2003)
Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)
⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.