Pure Trans-Resveratrol (from Polygonum cuspidatum)
Heart health & healthy ageingFunction & benefits
A polyphenol from the phytoalexin family; research suggests it activates sirtuins (especially SIRT1), which are linked to mitochondrial efficiency, and helps support the flexibility of the blood vessel lining and blood flow.
Dosage & how to use
| Recommended dose | Up to 150 mg trans-resveratrol daily (the EU authorised maximum) |
| Best time to take | With breakfast or a light meal that contains fat |
| Frequency | Once daily |
Best forms to choose
98% pure trans-resveratrol from Japanese knotweed (Polygonum cuspidatum); the trans form is the biologically active one.
Important warnings
The EU authorises trans-resveratrol as a novel food up to 150 mg a day for adults
Large doses (above 1000 mg) cause nausea and diarrhoea
Not for people with oestrogen-sensitive tumours, or during pregnancy and breastfeeding
Drug interactions
It has anti-platelet properties; take care with blood thinners (warfarin, aspirin). It may lower blood sugar, so take care with diabetes medication.
Related supplements
- Daily MultivitaminsGeneral health & immunity
- Omega-3 Fish OilGeneral & heart health
- Vitamin D3 (Cholecalciferol)General health & bones
- Magnesium (Glycinate/Citrate)General health & nerves
Scientific references
- EFSA Journal 2016;14(1):4368 (safety of synthetic trans-resveratrol as a novel food)
- Salehi B et al. Biomedicines 2018 — PMC6164842
Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)
⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.