Niacin (Vitamin B3) — Nicotinamide

B vitamins & energy

Function & benefits

Niacin contributes to normal energy-yielding metabolism, the normal function of the nervous system, normal psychological function, the maintenance of normal skin and mucous membranes, and the reduction of tiredness and fatigue (EFSA-authorised claims); it is the raw material for NAD+, which cells need to produce energy.

Dosage & how to use

Recommended dose	Nicotinamide: 16–50 mg daily (the NRV is 16 mg). Nicotinic acid: 10 mg daily at most
Best time to take	With a full meal at midday
Frequency	Once daily

Best forms to choose

Nicotinamide is the preferred form because it does not cause flushing; nicotinic acid causes redness and warmth of the face and neck (niacin flush) lasting about half an hour.

Important warnings

EFSA upper limits: 10 mg a day for nicotinic acid and 900 mg for nicotinamide

Large medicinal doses (above 500 mg) need liver enzyme monitoring and are for use under medical supervision only

Use with care if you have gout or a stomach ulcer

Drug interactions

It may strengthen blood pressure drugs and statins (higher risk of muscle pain at high doses) and may affect blood sugar control in people with diabetes.

View in the supplements guide

Related supplements

Scientific references

EFSA Journal 2009;7(9):1224 (niacin health claims)
Davidson MH. Am J Cardiol 2008 — PMID: 18375236

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.