Milk Thistle Seed Extract (Silymarin)

Liver health & antioxidants

Function & benefits

It contains a flavonoid complex called silymarin (mainly silybin); it helps protect liver cell membranes from oxidative stress and supports glutathione levels, and laboratory studies suggest it stimulates protein synthesis in liver cells.

Dosage & how to use

Recommended dose	150–300 mg standardized extract (80% silymarin)
Best time to take	With main meals
Frequency	2–3 times daily

Best forms to choose

Silybin phytosome, which is absorbed several times better than ordinary silymarin.

Important warnings

May have a mild laxative effect in the first days

Best avoided during pregnancy and breastfeeding because safety data are insufficient

Avoid it if you are allergic to plants of the daisy family (such as ragweed and chamomile)

Drug interactions

It may inhibit liver enzymes (CYP2C9 and CYP3A4) and so raise blood levels of some drugs, such as warfarin and some statins. It may strengthen glucose-lowering medication.

View in the supplements guide

Related supplements

Scientific references

European Medicines Agency (EMA): Community herbal monograph on Silybum marianum (L.) Gaertn., fructus
NIH National Center for Complementary and Integrative Health (NCCIH): Milk Thistle
Abenavoli L et al. Phytother Res 2010 — PMID: 20564545

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.