SAMe (S-Adenosyl-L-Methionine)

Mood & joints

Function & benefits

A compound the liver makes from the amino acid methionine and the body's main methyl donor; it takes part in making neurotransmitters (serotonin and dopamine), glutathione and cartilage components, and clinical studies suggest it supports mood and joint comfort and mobility.

Dosage & how to use

Recommended dose	400–800 mg daily
Best time to take	In the morning on an empty stomach, half an hour before breakfast, with a large glass of water
Frequency	Once daily

Best forms to choose

Enteric-coated SAMe tablets in sealed blister packs, because the molecule is very sensitive to moisture and stomach acid.

Important warnings

Not for people with bipolar disorder, as it may trigger manic episodes

May cause mild stomach upset, or sleeplessness if taken in the evening

Avoid during pregnancy and breastfeeding, as safety data are insufficient

Drug interactions

Critical warning (serotonin syndrome): never combine it with antidepressants (SSRIs, SNRIs, MAO inhibitors), 5-HTP, St John's wort, tramadol or triptans.

View in the supplements guide

Related supplements

Scientific references

Delle Chiaie R et al. Am J Clin Nutr 2002 — PMID: 12418499
Soeken KL et al. J Fam Pract 2002 — PMID: 12019049

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.