L-Glutamine

Digestion & recovery

Function & benefits

The most abundant amino acid in blood and muscle; it is the main fuel for the cells lining the small intestine and for immune cells, and helps support the tight junctions between gut cells and the integrity of the gut barrier.

Dosage & how to use

Recommended dose	5–10 g daily (up to 15–20 g in split doses for gut-lining protocols)
Best time to take	After training or before bed, dissolved in cold water on an empty stomach
Frequency	1–2 times daily

Best forms to choose

Plant-fermented free-form L-glutamine powder for the highest purity.

Important warnings

Dissolve it in cold or lukewarm water, as heat reduces its stability

Not for people with hepatic encephalopathy or advanced liver cirrhosis

Use with caution if you have a neurological disorder

Drug interactions

It may reduce the effect of epilepsy and seizure medication because glutamine is converted in the brain to excitatory glutamate; consult a doctor before combining them.

View in the supplements guide

Related supplements

Scientific references

Kim MH, Kim H. Int J Mol Sci 2017 — PMID: 28498331
NIH National Library of Medicine (MedlinePlus): Glutamine

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.