Citrulline Malate 2:1
Performance & heart healthFunction & benefits
A 2:1 combination of L-citrulline and malic acid; citrulline raises arginine and nitric oxide to support blood flow, while malic acid enters the Krebs cycle to support energy production, helping you complete extra repetitions in hard training.
Dosage & how to use
| Recommended dose | 6–8 g dissolved in water |
| Best time to take | 30–45 minutes before training |
| Frequency | Once before training |
Best forms to choose
Check for a documented 2:1 citrulline-to-malate ratio and avoid 1:1 products.
Important warnings
Its acidity may cause heartburn in people with gastritis or an active ulcer; drink it with plenty of water
Drug interactions
It interacts with heart nitrates, PDE-5 inhibitors (sildenafil, tadalafil) and blood pressure medication and may cause a drop in blood pressure.
Related supplements
- Pure TaurinePerformance & heart health
- L-Arginine (Free Form / AAKG)Performance & heart health
- Caffeine AnhydrousEnergy & focus
- Pre-Workout FormulaEnergy & fitness
Scientific references
- Pérez-Guisado J, Jakeman PM. J Strength Cond Res 2010 — PMID: 20386132
Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)
⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.