Vitamin B-Complex (Active Methylated)

Energy & nervous system

Function & benefits

The eight B vitamins act as coenzymes that turn carbohydrates, fats and proteins into energy; they contribute to normal energy-yielding metabolism, normal functioning of the nervous system, normal red blood cell formation and the reduction of tiredness and fatigue (EFSA).

Dosage & how to use

Recommended dose	1 capsule daily (B6 no more than 12 mg)
Best time to take	With breakfast; best avoided in the evening as it can increase alertness
Frequency	Once daily

Best forms to choose

Bioactive forms: methylcobalamin (B12), methylfolate (5-MTHF) instead of synthetic folic acid, and pyridoxal-5-phosphate (P5P) for vitamin B6.

Important warnings

Bright yellow urine is normal and harmless, caused by excreted vitamin B2

EFSA 2023 upper limit: daily vitamin B6 should not exceed 12 mg to avoid damage to the peripheral sensory nerves

Drug interactions

Vitamin B6 can reduce the effect of levodopa in Parkinson's disease when it is taken without carbidopa. Metformin, birth control pills, some diuretics and acid-reducing drugs lower B12 and folate levels.

View in the supplements guide

Related supplements

Scientific references

EFSA Scientific Opinion on the Tolerable Upper Intake Level for vitamin B6 (2023)
NIH Office of Dietary Supplements (ODS): B vitamins fact sheets
Kennedy DO. Nutrients 2016 — PMID: 26828517

📚 Published sources and research: European Food Safety Authority (EFSA) • National Institutes of Health (NIH - ODS) • PubMed / Cochrane databases

Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)

⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.