L-Citrulline (Malate 2:1)
Energy & sports performanceFunction & benefits
An amino acid that the kidneys efficiently convert into L-arginine, supporting nitric oxide (NO) production, widening of the blood vessels and blood flow to the muscles.
Dosage & how to use
| Recommended dose | 6–8 g citrulline malate (or 3–5 g pure citrulline) |
| Best time to take | 45–60 minutes before training |
| Frequency | On training days |
Important warnings
Mild stomach upset at very high doses; start with 3 g
Safe for the kidneys and liver within the recommended doses
Drug interactions
Blood pressure warning: it interacts strongly with erectile dysfunction drugs (PDE5 inhibitors such as Viagra and Cialis), nitrates and blood pressure medicines, and may cause a sharp drop in blood pressure.
Scientific references
- Pérez-Guisado J, Jakeman PM. J Strength Cond Res 2010 — PMID: 20386132
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Content last updated: 17 October 2026 · Based on published sources and research (EFSA / NIH / PubMed)
⚖️ Medical disclaimer: The information and data provided here are for health education and nutritional guidance only. They are not a medical diagnosis and never replace a direct consultation with your doctor or pharmacist. Always consult your doctor before starting any supplement, especially during pregnancy or breastfeeding or when taking long-term medication.